| Name | Notability | References |
| Dianna Agron | actress, known for role as Quinn Fabray on the TV series Glee | |
| Charles Coburn | Academy Award-winning actor | |
| Desmond Harrington | 2004 Málaga International Week of Fantastic Cinema Award-winning actor | |
| J. G. Hertzler | actor from Star Trek Deep Space Nine series | |
| Miriam Hopkins | Golden Globe and Academy Award-nominated actress | |
| James Keach | actor and Producers Guild Awards-nominated producer | |
| Stacy Keach | Academy Award-nominated and Golden Globe-winning actor | |
| Isabel Keating | Tony Award-nominated actress and singer | |
| Mammy Lou | world's oldest actress | |
| Alicia Rhett | actress in the film Gone with the Wind | |
| Diana Scarwid | Academy Award and Emmy-nominated actress | |
| Fredi Washington | 1930s film actress who appeared in The Emperor Jones and Imitation of Life | |
| Name | Notability | References |
| Robert Houston Anderson | cavalry and artillery officer in Confederate States Army during American Civil War | |
| James Dunwoody Bulloch | Confederate States of America's chief foreign agent in Great Britain during Civil War | |
| William V. Davis | Vice Admiral and Naval Aviator in the United States Navy, commanded the | |
| Leonard Matlovich | Purple Heart and Bronze Star recipient; gay rights activist | |
| Moxley Sorrel | youngest general in Confederate Army | |
| Julian Larcombe Schley | former Governor of Panama Canal Zone | |
| Josiah Tattnall | officer in U.S. Navy during War of 1812, Second Barbary War, and Mexican–American War | |
| William F. Train | U.S. Army lieutenant general and veteran of World War II, Korean War and Vietnam War | |
| Name | Notability | References |
| Baroness | metal music band whose 2007 album was named Album of the Year by heavy metal magazine Revolver | |
| Big Boi | rapper from Grammy Award-winning hip-hop music duo OutKast | |
| Camoflauge | rapper | |
| Mike Curb | Curb Records and Word Label Group executive; Lieutenant Governor of California | |
| Stephanie Edwards | 11th-place finalist on American Idol, season 6 | |
| Kylesa | metal music band | |
| DJ Lord | music turntablist currently with hip hop group Public Enemy | |
| Kate McTell | blues musician; former wife of blues musician Blind Willie McTell | |
| Johnny Mercer | composer of more than 1,000 songs; received 19 Academy Award nominations; wrote music for Broadway shows; singer; co-founded Capitol Records | |
| James Moody | jazz musician, composer, actor known for his song "Moody's Mood for Love" | |
| James Lord Pierpont | songwriter of Jingle Bells; uncle of J.P. Morgan | |
| Ben Riley | hard bop drummer who worked with artists including Thelonious Monk and Stan Getz | |
| Sahib Shihab | jazz saxophonist and flautist who performed with Thelonious Monk, Art Blakey Dizzy Gillespie, and Quincy Jones | |
| Showbread | Christian post-hardcore alternative rock band | |
| Squad 5-O | Christian ska-punk | |
| Tom Turpin | composer credited with first published ragtime by an African-American | |
| Jared Wade | country music singer-songwriter, from Savannah suburb Pooler | |
| Trummy Young | swing-era trumbonist who performed with Charlie Parker, Dizzy Gillespie, Jazz at the Philharmonic and Louis Armstrong All-Stars | |
| Name | Notability | References |
| Francis S. Bartow | Confederate States of America political leader, and military officer during the early months of the American Civil War | |
| Joseph Bryan | U.S. Representative from Georgia who served in the 8th and 9th U.S. Congresses | |
| William Bellinger Bulloch | Senator from Georgia appointed as a Democratic Republican to the United States Senate who served from April 8, 1813 until November 6, 1813 | |
| Robert M. Charlton | U.S. Senator representing Georgia from 1852-1853 | |
| Alfred Cuthbert | U.S. Representative and Senator | |
| Samuel Elbert | Governor of the State of Georgia | |
| Ion Farris | Speaker of the Florida House of Representatives | |
| Joseph Habersham | delegate to the Congress of the Confederation ; member of the convention which ratified the U.S. Constitution ; 3rd Postmaster General of the United States | |
| F. Ross Holland, Jr. | National Park Service historian noted for his books on lighthouses | |
| William Houstoun | delegate to the Continental Congress and to the United States Constitutional Convention | |
| Bob Inglis | twice elected to represent South Carolina's 4th congressional district in the United States House of Representatives | |
| Otis Johnson | former mayor of Savannah, Georgia, first elected in 2004 | |
| George Jones | U.S. Senator serving from August 27, 1807, to November 7, 1807 | |
| Edward Langworthy | delegate to the Continental Congress from Georgia and signature to the U.S. Articles of Confederation | |
| John Milledge | elected to Second Congress and Fourth and Fifth Congresses ; again elected ; U.S. Senate in 10th U.S. Congress as the President pro tempore of the Senate | |
| Dennis Smelt | U.S. Representative to the 9th, 10th and 11th United States Congresses | |
| Josiah Tattnall | U.S. Senator and Georgia governor | |
| Thomas Telfair | elected to the 13th and 14th United States Congresses | |
| Name | Notability | References |
| Conrad Aiken | Pulitzer Prize for Poetry recipient for Selected Poems | |
| Henry Coppée | author, educator, first president of Lehigh University | |
| Charles Elmore | African American scholar, jazz historian, and educator | |
| Bruce Feiler | journalist; formulated Feiler Faster Thesis; produced TV mini-series Abraham: A Journey to the Heart of Three Faiths | |
| Chris Fuhrman | author of The Dangerous Lives of Altar Boys | |
| Anne Green | novelist, memoirist, translator; sister of Julien Green | |
| Al Jaffee | writer and cartoonist for Timely Comics, Atlas Comics, and Mad Magazine | |
| James Alan McPherson | writer and essayist, awarded 1978 Pulitzer Prize for fiction for short story collection Elbow Room | |
| Ward Morehouse | theater critic and newspaper columnist for Atlanta Journal, New York Tribune, New York Herald Tribune New York Sun | |
| Flannery O'Connor | writer and novelist, namesake of Flannery O'Connor Award for Short Fiction | |
| Charles Perry | author of Portrait of a Young Man Drowning, made into film Six Ways to Sunday | |
| Sally Quinn | author, reporter for Washington Post, co-anchor of CBS Morning News with reporter Hughes Rudd | |
| Mary Schmich | columnist for Chicago Tribune; author of Wear Sunscreen; writer of Brenda Starr, Reporter comic strip | |
| Frank Lebby Stanton | lyricist, columnist for Atlanta Constitution, author of words for "Just Awearyin' for You" | |
| Name | Notability | References |
| Steve Charnovitz | law professor best known as scholar on international trade law | |
| Curtis Cooper | civil rights leader, served as president of Savannah Chapter of NAACP | |
| Ralph Mark Gilbert | civil rights leader; as president of Savannah Chapter of NAACP, helped initiate hiring of Savannah's first African-American police officers with other black city employees | |
| William Gardner Hale | classical scholar best known as an original teacher on questions of syntax | |
| Estelle Brown Hamilton | Entrepreneur, owned a beauty school in Harlem in the 1910s and 1920s | |
| Brittany Hatch | contestant on America's Next Top Model, season 8 | |
| W. W. Law | civil rights leader; influential in establishment of Ralph Mark Gilbert Civil Rights Museum, King-Tisdell Cottage Museum, Beach Institute of African American Culture, and Negro Heritage Trail Tour | |
| Jack Leigh | photographer best known for the "Bird Girl" statue photograph on the cover of the novel Midnight in the Garden of Good and Evil | |
| Juliette Gordon Low | founder of Girl Scouts of the USA | |
| Sonny Seiler | owner of the University of Georgia mascot Uga | |
| Kirk Varnedoe | art historian and curator of painting and sculpture at the New York City Museum of Modern Art | |
| Akintunde Warnock | comedian | |
| Frank Wills | security guard at Watergate break-in | |
| Ellen Axson Wilson | first wife of Woodrow Wilson and First Lady of the United States from 1913 until her death | |
| Rufus Youngblood | bodyguard to Lyndon B. Johnson at the assassination of John F. Kennedy in Dallas, Texas; resided in later years and died in Savannah | |
