List of systemic diseases with ocular manifestations An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes. Diabetes , for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more. Other diseases such as acquired immunodeficiency syndrome and hypertension are commonly found to have associated ocular symptoms.Systemic allergic diseases Asthma Atopic dermatitis Atopic eczema Hay fever Urticaria Vernal conjunctivitis Acne rosacea Albinism Atopic dermatitis Behçet's disease Cicatricial pemphigoid Ehlers–Danlos syndrome Epidermolysis bullosa Erythema multiforme Goltz–Gorlin syndrome Ichthyosis Incontinentia pigmenti Nevus of Ota Pemphigus Pseudoxanthoma elasticum Psoriasis Stevens–Johnson syndrome Vogt–Koyanagi–Harada syndrome Xeroderma pigmentosumPhacomatoses Angiomatosis retinae Ataxia telangiectasia Encephalotrigeminal angiomatosis Neurofibromatosis Tuberous sclerosis Wyburn–Mason syndromeCollagen diseases Ankylosing spondylitis Dermatomyositis Periarteritis nodosa Reactive arthritis Rheumatoid arthritis Ehlers-Danlos Syndrome Sarcoidosis Scleroderma Systemic lupus erythematosus Temporal arteritis Relapsing polychondritis Granulomatosis with polyangiitis 50-60% have ophthalmologic manifestations, which can be a presenting feature in a minority of patients. Orbital disease is the most common manifestation, and may result in proptosis , restrictive ophthalmopathy , chronic orbital pain, and in chronic cases, orbital retraction syndrome and intractable socket pain. Granulomatosis with polyangiitis may also cause inflammation of the optic nerve , ophthalmoplegia , conjunctivitis, keratitis , scleritis , episcleritis , dacrocystitis , nasolacrimnal duct obstruction, dacroadenitis , uveitis , and retinal vasculitis . Varicella Rubeola Rubella Variola Vaccinia Herpes simplex Herpes zoster Mumps Infectious mononucleosis Influenza Cytomegalic inclusion disease Pharyngoconjunctival fever Epidemic keratoconjunctivitis Human immunodeficiency virus Ebola Rift Valley Fever Dengue Hantavirus Gonorrhea Brucellosis Diphtheria Lyme disease Sepsis Tularemia Leprosy Tuberculosis SyphilisSystemic protozoal infections Lymphogranuloma venereum Inclusion conjunctivitis Malaria Toxoplasmosis Candida albicans Histoplasmosis Coccidioidomycosis Cryptococcus Metastatic fungal endophthalmitis Actinomyces Streptothrix Cysticercosis Echinococcosis Toxocariasis Trichinosis Onchocerciasis Loiasis Cri-du chat syndrome Schmid–Fraccaro syndrome Turner's syndrome Ring-D chromosome Monosomy-G syndrome Trisomy 13 Trisomy 18 Trisomy 21 Deletion of long arm of chromosome 18 Deletion of chromosome 18 Ciliopathic genetic syndromes—A number of widely variant genetic disorders with occular phenotypes have been identified with genotypical ciliopathy.Hematologic diseases AnemiaCardiovascular diseases Cardiovascular diseases Occlusive vascular disease Occlusive vascular disease Venous occlusive disease Endocarditis Myxoma Aortic arch syndrome Pre-eclampsia Thromboangiitis obliterans Hereditary telangiectasiaEndocrine diseases Cushing's disease Addison's disease Diabetes mellitus Hyperparathyroidism Hypoparathyroidism Hyperthyroidism HypothyroidismGastrointestinal and nutritional disorders Alcoholism Crohn's disease Liver disease Malnutrition Peptic ulcer disease Pancreatic disease Regional enteritis or ulcerative colitis Vitamin A deficiency Vitamin B deficiency Vitamin C deficiency Hypervitaminosis A, B, and D Whipple's diseaseMetabolic disorders Albinism Alkaptonuria Amyloidosis Chediak–Higashi syndrome Cystinosis Fabry's disease Galactosemia Gaucher's disease Gout Hemochromatosis Histiocytosis Homocystinuria Lipidoses Marfan's syndrome Weill–Marchesani syndrome Mucopolysaccharidosis Niemann–Pick disease Osteogenesis imperfecta Wilson's diseaseMusculoskeletal disease Albright's disease Apert syndrome Conradi's syndrome Craniofacial syndromes Facial deformity syndromes Muscular dystrophy disorders Myasthenia gravis Osteogenesis imperfecta Paget's diseasePulmonary diseases Asthma Bronchogenic carcinoma Bronchiectasis Cystic fibrosis of the pancreas Emphysema Pneumonias TuberculosisRenal disease Alport's syndrome Azotemia Lowe's syndrome Medullary cystic disease Nephrotic syndrome Renal transplantation Wilms' tumorNeoplastic diseases with ocular metastases Carcinoma and sites of primary lesions Blood Breast Colon Kidney Lung Genital organs Skin Gut Thyroid
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