In August 1978 Lacalle was sent three bottles of wine tainted with poison addressed to himself and two fellow National Party members who had been trying to negotiate a way out of the military regime. Lacalle's wife warned him against the suspicious gift, but Heber's mother drank a glass, dying immediately. The case remains unsolved.
Vice-President of Senate
When democracy was restored in 1984 he was elected senator, and became vice-president of the Senate.
In 1989 he ran for the presidency for his faction, Herrerismo, with running-mate Gonzalo Aguirre. In the subsequent elections in November 1989, the National Party defeated the rival Colorado Party and Broad Front. Lacalle received the most votes within his party, defeating Carlos Julio Pereyra and Alberto Zumarán, and thus was elected President of Uruguay, taking office on March 1, 1990 for a five-year term.
Tenure
Upon taking office, Lacalle sent parliament a tax reform bill which was immediately passed with the support of the Colorado Party. Sales tax were increased from 21% to 22% income tax was increased and a few other taxes were created. During his rule, he encouraged a free market program, participated in the Brady bonds plan to alleviate foreign debt obligations, and was a co-founder of the Mercosur, along with the presidents of Paraguay, Brazil, and Argentina, which came into effect with the Treaty of Asunción in 1991. In 1992, support for his economic reforms suffered a heavy blow when one of his most significant initiatives, a plan to privatize Uruguay's state-owned companies, was rejected by referendum. In the 1994 national elections, he selected his Interior Minister, Juan Andrés Ramírez to be the presidential candidate of the Herrerismo faction. The National Party narrowly lost the elections to the Colorado Party. Among several prominent politicians who took part in his government are Héctor Gros Espiell, Sergio Abreu, Juan Andrés Ramírez, Carlos Cat and Ignacio de Posadas. .
Later runs for the presidency
In 1999, he won his party's primary elections against Juan Andrés Ramírez and several other candidates, and was a candidate for presidency again. However, a string of accusations about corruption in his government damaged his chances. Ramírez's departure from active politics after losing the primary was the final blow, and Lacalle came in third place with 22.3% of the votes in the general elections. Lacalle ran again for president in the 2004 elections, but the other party leaders had gathered around a single opposing candidate, Jorge Larrañaga, who defeated him in the primaries by a 2-to-1 margin. In 2009, he ran for the presidency again, this time defeating Jorge Larrañaga in the June primaries. By winning the primary election, he became head of the governing board of the party. He lost the presidential elections to José Mujica in a run-off election in November. Lacalle is a member of the Club de Madrid. and he is member of the board of the Public Affairs Committee of the Jerusalem Summit.