After finishing school, Meskin went to work for Eisner & Iger, one of the most prominent "packagers" who supplied complete comic books to publishers testing the waters of the emerging medium. There he did pencils for Fiction House's "Sheena, Queen of the Jungle" in Jumbo Comics. In late 1939, he also worked for the packager Harry "A" Chesler, producing material for the MLJ/Archie Comics characters as Ty-Gor son of Tiger, The Press Guardian, Bob Phantom, Mr. Satan, The Shield, Wizard, and Dick Storm between 1939 and 1942. In 1941, Meskin started at National Comics, drawing stories for the characters Vigilante, Wildcat, Starman and Johnny Quick. He told comics historian and artistJim Steranko that during this period his art style was heavily influenced by film: "Citizen Kane influenced us a great deal, all of us. We were very excited about it and spent quite a bit of time discussing it, employing its elements in our work. There was a contest as to who saw it the most times". In his "Johnny Quick" superhero feature, which appeared from Sept. 1941 through Jan. 1946 in More Fun Comics, Meskin uniquely conveyed the flash-like quick moving actions of Johnny Quick by drawing close knit snapshot-like drawings one next to the other, of the hero in motion. He didn't copy DC Comics' "The Flash" or Timely Comics' "The Wizard" rendering technique of blurred windstreams following those superheroes' every move. During his time at National, Meskin also did work for Marvel Comics, Gleason and Nedor Comics, Spark, and other publishers. At Nedor he worked on the Black Terror as well as on the Fighting Yank together with Jerry Robinson. From 1944 to 1946, he and Robinson formed a studio which produced material for the short-lived publisher Spark Publications. In 1949 Meskin left National and joined the Simon & Kirby, studio where he worked on a variety of titles such as Boys' Ranch and Prize Comics. He returned to National in 1956, where he created the feature "Mark Merlin" and also worked on a large number of war, science fiction and horror titles. In 1965, Meskin left the comics world and became a commercial illustrator and storyboard artist in the advertising industry, working at BBD&O until his retirement in 1982. For the next 13 years he worked as a volunteer at St. Josephs Nursing Home in Yonkers.