Nicotinamide-nucleotide adenylyltransferase
In enzymology, nicotinamide-nucleotide adenylyltransferase are enzymes that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ATP and nicotinamide ribonucleotide, whereas its two products are diphosphate and NAD+.
This enzyme participates in nicotinate and nicotinamide metabolism.
Humans have three protein isoforms: NMNAT1, NMNAT2, and NMNAT3. Mutations in the NMNAT1 gene lead to the LCA9 form of Leber congenital amaurosis. NMNAT2 is critical for neurons: loss of NMNAT2 is associated with neurodegeneration. All NMNAT isoforms reportedly decline with age.Belongs to
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups. The systematic name of this enzyme class is ATP:nicotinamide-nucleotide adenylyltransferase. Other names in common use include NAD+ pyrophosphorylase, adenosine triphosphate-nicotinamide mononucleotide transadenylase, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyltransferase, and NMN adenylyltransferase.As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,, and.
