Beginning in 1936, Japanese ophthalmologist Tsutomu Sato conducted research in anterior and posterior keratotomy, an early form of refractive surgery that attempted to treat keratoconus, myopia and astigmatism by making incisions in the cornea. In 1974, Svyatoslav Fyodorov removed glass from the eyeof a boy who had been in an accident. The boy, who required eyeglasses for correction of myopia caused by astigmatism, fell off his bicycle. His glasses shattered on impact, and glass particles lodged in both eyes. To save the boy's vision, Fyodorov performed an operation which consisted of making numerous radial incisions extending from the pupil to the periphery of the cornea in a radial pattern like the spokes of a wheel. After the glass was removed by this method and the cornea healed, Fyodorov found that the boy's visual acuity had improved significantly.
Procedure
In RK, incisions are made with a diamond knife. Incisions that penetrate only the superficial corneal stroma are less effective than those reaching deep into the cornea, and consequently, incisions are made quite deep. One study cites incisions made to a depth equivalent to the thinnest of four corneal-thickness measurements made near the center of the cornea. Other sources cite surgeries leaving 20 to 50 micrometres of corneal tissue unincised.
The healing corneal wounds consist of newly abutting corneal stroma, fibroblastic cells, and irregular fibrous connective tissue. Closer to the wound surface lies the epithelial plug, a bed of the cells that form the normal corneal epithelium which have fallen into the wound. Often this plug is three to four times as deep as the normal corneal epithelium layer. As the cells migrate from the depth of the plug up to the surface, some die before reaching it, forming breaches in the otherwise healthyepithelial layer. This, consequently, leaves the cornea more susceptible to infections. The risk is estimated to be between 0.25% and 0.7% Healing of the RK incisions is very slow and unpredictable, often incomplete even years after surgery. Similarly, infection of these chronic wounds can also occur years after surgery, with 53% of ocular infections being late in onset. The pathogen most commonly involved in such infections is the highly virulent bacterium Pseudomonas aeruginosa.
Complications
Large epithelial plugs may cause more scattering of light, leading to the appearance of visual phenomena such as flares and starbursts — especially in situations such as night driving, where the stark light of car headlights abounds. These dark conditions cause the pupil to dilate, maximizing the amount of scattered light that enters the eye. In cases where large epithelial plugs lead to such aggravating symptoms, patients may seek further surgical treatment to alleviate the symptoms. Increasing altitude can cause partial blindness in people who have undergone RK, as discovered by mountaineer Beck Weathers during the 1996 Mount Everest disaster. The incisions of RK are used to relax the steep central cornea in patients with myopia. The original technique — consisting of incisions from periphery to center — was called "the Russian technique", while the later advances of performing controlled incision from center to periphery was called "the American technique". RK enjoyed great popularity during the 1980s, and was one of the most studied refractive surgical procedures. Its 10-year data was published as the PERK study, which proved the onset of progressive hyperopia — often found a decade after the original surgery — is due to continued flattening of the central cornea. A conceptually opposite technique of using hexagonal incisions in the periphery of the cornea is known has hexagonal keratotomy, which was used to correct low degrees of hyperopia. The idea behind HK was to make six peripheral incisions forming a hexagon around the central cornea to steepen the hyperopic flat cornea and, thereby, focus the rays of light more precisely onto the retina. These incisions can be of two types, either connecting or non-connecting. RK may be performed with different types, numbers, and patterns of incisions. They can have 4, 8, 12, 16 or 32 incisions made in a number of patterns and orientations based on refractive errors, surgeon style and surgeon training. Many of these patients have had additional incisional surgeries like astigmatic keratotomy, where incisions are placed at the steepest points of the cornea in people with astigmatism to relax and transform the cornea to a more spherical shape. Some people have had a combination of intraocular surgeries, such as pseudophakic or phakic implants, along with their keratotomies and many underwent "purse-string" suturing to control over-correction. Due to the instability of the cornea seen with many age-related pathologies, it may be difficult to address visual acuity satisfactorily in people who have undergone RK surgery but who later develop presbyopia. In these situations, factors to be considered include: Primary visual factors: Secondary visual factors:
Visual rehabilitation after RK
The PERK study demonstrated that people who undergo RK continue to drift toward hyperopia. Additionally, many of these people have reached the age where presbyopia occurs. Some also develop cataracts. Their vision can still be restored with Epi-LASIK, photorefractive keratectomy, LASIK or phakic lens extraction, or cataract surgery. The corneal curvature has to remeasured and modified by history, central keratometry, or contact lens method.
