Relaxin receptor
The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
receptor/gene | ligands | activates | inhibits |
relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases | ||
relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | ||
relaxin 3 | Erk1/2 signaling | adenylate cyclase | |
relaxin 3, insulin-like 3 | adenylate cyclase |