Retinoic acid receptor alpha
Retinoic acid receptor alpha, also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.Function
signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.Clinical significance
Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia. The most frequent translocation is t, which fuses the RARA gene with the PML gene.Interactions
Retinoic acid receptor alpha has been shown to interact with:
- BAG1,
- CLOCK,
- CCND3,
- NCOA6,
- NCOR1,
- NCOR2,
- NPAS2,
- NRIP1,
- NR0B2,
- NR4A2,
- PML
- RXRA.
- Src,
- TADA3L, and
- ZBTB16.
