Zinc finger and BTB domain-containing protein 16
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:
- Angiotensin II receptor type 1,
- BCL6,
- BMI1,
- Calcitriol receptor,
- FHL2,
- GATA1,
- GATA2,
- HDAC1,
- HDAC4,
- HDAC6,
- Heparin-binding EGF-like growth factor,
- Histone deacetylase 5,
- Nuclear receptor co-repressor 2,
- Promyelocytic leukemia protein
- RUNX1T1,
- Retinoic acid receptor alpha,
- SIN3A,
- SIN3B, and
- ZBTB32.
