Ribokinase
In enzymology, a ribokinase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are ATP and -ribose, whereas its two products are ADP and -ribose 5-phosphate.
The systematic name of this enzyme class is ATP:-ribose 5-phosphotransferase. Other names in common use include deoxyribokinase, ribokinase , and -ribokinase. This enzyme participates in pentose phosphate pathway.
Ribokinase belongs to the phosphofructokinase B family of sugar kinases. Other members of this family include adenosine kinase, inosine-guanosine kinase, fructokinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs and the enzymatic activity of this family of protein generally shows a dependence on the presence of pentavalent ions. The conserved NXXE motif, which is a distinctive property of the PfkB family of proteins, is involved in pentavalent ion dependency. The structures of RK and several other PfK family of proteins have been determined from a number of organisms. Despite low sequence similarity between AdK and other PfkB family of proteins, these proteins are quite similar at structural levels.As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and.
