SMYD3


SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.

Function

SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.

Model organisms

s have been used in the study of SMYD3 function. A conditional knockout mouse line, called Smyd3tm2aWtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.

Interactions

SMYD3 has been shown to interact with Heat shock protein 90kDa alpha, member A1 and POLR2A.
SMYD3 trimethylates a lysine residue on MAP3K2, which causes crosstalk into the MAP kinase signaling pathway in Ras-driven cancers.