For some time, she worked as a physical therapist at Harlem Hospital, and also assisted pregnant women with a natural birthing practice. Henderson-Holmes later held a number of teaching posts, including positions at Marymount College, Touro College, Eugene Lang College, the College of New Rochelle, and Sarah Lawrence College. She became poet-in-residence at the University Heights High School, and was appointed assistant professor at Syracuse University from 1990 until her death in 2001. Henderson-Holmes was actively involved in initiatives such as Poets and Writers, Art Against Apartheid, and the National Council of American-Soviet Friendship. Between 1982 and 1992, she received two Goodman City College Awards and a MacDowell Fellowship. In 1983, she was recipient of a Northstar Grant and a New York CAPS Poetry Fellowship. In 1990, Henderson-Holmes received the William Carlos Williams Award for her first collection of poems, titled Madness and a Bit of Hope. The collection, like much of Henderson-Holmes' work, focused on exploring "the political realities in the lives of women". She published her second book of poetry in 1994, called Daily Bread. In 1999, Henderson-Holmes received a fellowship from the New York Foundation of the Arts, but this award was followed soon after by a diagnosis of cancer. She developed a series of poetic narratives about her diagnosis and subsequent treatment, calling this poetic cycle "C-ing Colors". Henderson-Holmes said that cancer made her feel "diminished", and that "in order to outlive this disease, I needed more of me—not less—more weight, more desire", which prompted her to write more poetry. Henderson-Holmes died on April 8, 2001, aged 50.
Reception
Despite attracting few critical analyses, Henderson-Holmes was popular in the New York poetry community, and her work has been published in multiple anthologies and editions. One critic from the Amsterdam News described Henderson-Holmes as "positive, fiery, revolutionary", commenting that her "eloquent, yet stinging, poignant poetic words pierce souls". Writer and poet June Jordan wrote that Henderson-Holmes gave readers "spine and joy and the grace of laughter – with a surety of craft that cannot fail".
Personal life
Henderson-Holmes married film producer Preston Holmes, and the couple had one daughter named Naimah.