S-phase kinase-associated protein 1
S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.
This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.Interactions
SKP1A has been shown to interact with:
- BTRC,
- CACYBP,
- CDCA3,
- CDK9,
- CUL1,
- FBXL3,
- FBXO4,
- FBXO5,
- FBXO7,
- FBXW2,
- FBXW7, and
- SKP2.
