Wisniewski became the first Penn State Football student-athlete to be named an ESPN Academic All-American three times, having been a first team selection in 2008, 2009, and 2010. He became Penn State's 95th first team All-American at the conclusion of the 2010 season. Prior to the 2011 NFL Draft, Wisniewski was regarded as one of the top centers prospects available.
Professional career
Oakland Raiders
The Oakland Raiders selected Wisniewski in the second round of the 2011 NFL Draft. His uncle, Steve Wisniewski, was an ×8 Pro bowl guard for the Raiders and was selected in the second round of the 1989 NFL Draft. Wisniewski elected not to wear No. 76 which was worn by his uncle for 13 seasons and was an available choice. He stated that he wished to create his own legacy, opting for his college No. 61 instead. He signed with the Raiders shortly before the beginning of the 2011 training camp. At the beginning of the 2011 season, coach Hue Jackson named Wisniewski the Raiders' starting left guard, placed between Samson Satele at center and Jared Veldheer at left tackle. On opening day of the 2011 NFL season, the offensive line cleared the way for 190 rushing yards and a victory over the Denver Broncos. Wisniewski was named the Pepsi NFL Rookie of the Week for Week 3 of the 2011 NFL season, after the Oakland offensive line cleared the way for 234 rushing yards and allowing only one sack against the New York Jets. His lead block on a pivotal fourth-quarter touchdown run gave Oakland a two-score lead. On January 2012, Wisniewski was named to the Pro Football Weekly All-Rookie team for his outstanding rookie season as starting left guard. Wisniewski helped pave the way for the NFL's 7th ranked rushing attack and anchored an offensive line that only allowed 25 sacks, tied for 3rd best in the NFL. With the departure of Samson Satele to the Indianapolis Colts in the 2012 offseason, Wisniewski became the Raiders' starting center.
Jacksonville Jaguars
Wisniewski signed a one-year contract with the Jacksonville Jaguars on April 18, 2015. He started all 16 games at center for the Jaguars in 2015.
Philadelphia Eagles
On April 4, 2016, Wisniewski signed a one-year contract with the Philadelphia Eagles. On March 10, 2017, he signed a three-year contract extension with the Eagles. Wisniewski played in 14 games and started 11 in the 2017 NFL season. The team went 13-3 and earned a first round bye. The Eagles defeated both the Atlanta Falcons and Minnesota Vikings to reach Super Bowl LII. The Eagles defeated the New England Patriots 41-33 to win their first Super Bowl. In 2018, Wisniewski entered the season as the starting left guard, but was then benched in Week 5 in favor of Isaac Seumalo. He started the final three weeks of the regular season after Seumalo was sidelined with a pectoral injury. On March 11, 2019, the Eagles declined the team option on Wisniewski's contract, making him an unrestricted free agent. On May 13, 2019, Wisniewski re-signed with the Eagles. He was released during final roster cuts on August 31, 2019.
On October 9, 2019, Wisniewski was signed by the Kansas City Chiefs. He won his second Super Bowl championship when the Chiefs defeated the San Francisco 49ers in Super Bowl LIV by a score of 31-20.
Pittsburgh Steelers
On March 26, 2020, the Pittsburgh Steelers signed Wisniewski to a two-year, $2.85 million contract that includes a signing bonus of $375,000. He joined his hometown team as a replacement for Ramon Foster, who announced his retirement after 11 seasons.
Personal life
Wisniewski comes from an athletic family; his father Leo Wisniewski played four seasons for the Colts as a nose tackle, while his uncle Steve Wisniewski was an eight-time Pro Bowl guard with the Raiders and served as the team's assistant offensive line coach in 2011. He played in the 2007 U.S. Army All-American Bowl. Wisniewski is a Christian.
