Lombardozzi graduated from Atholton High School in 2007. A player on the school's varsitybaseball team, he was named a preseason third-team Rawlings high school All-American in 2005. Lombardozzi was playing with the Holyoke Blue Sox in the New England Collegiate Baseball League when he was selected by the Washington Nationals in the 19th round of the 2008 Major League Baseball Draft out of St. Petersburg College. Lombardozzi spent 2009 with the Class AHagerstown Suns and recorded a.296 batting average with three home runs, 58 runs batted in, and 16 stolen bases in 126 games. Prior to the 2010 season, Lombardozzi was ranked as the Nationals' 15th best prospect. He split the season between the Class-A Advanced Potomac Nationals and Double-A Harrisburg Senators, hitting.293 with six home runs, 49 RBIs, 35 doubles, 11 triples, and 24 stolen bases in 137 games. After reporting back to Harrisburg to start the 2011 season, Lombardozzi earned a promotion to the Triple-ASyracuse Chiefs after hitting.309 in 65 games. He was called up to the majors for the first time on September 6, 2011. Lombardozzi was granted a spot on the Nationals 25-man roster for the 2012 season after a productive spring. His productivity continued into the regular season with a.333 batting average as a semi-regular through May 20. On June 4, 2013 he hit his first career walk-off, a sacrifice fly in a 3–2 victory over the Mets.
On March 24, 2014, before playing in a regular-season game with the Tigers, Lombardozzi was traded to the Baltimore Orioles in exchange for Alex Gonzalez. On March 29, 2014 it was announced that Lombardozzi had made the Opening Day roster for the Orioles. He was optioned to the Triple-A Norfolk Tides on May 1 when Manny Machado returned from the disabled list. Lombardozzi was outrighted off the Orioles roster on December 8, 2014.
Pittsburgh Pirates
Lombardozzi was acquired by the Pittsburgh Pirates on February 3, 2015.
On October 26, 2015, the Chicago White Sox signed Lombardozzi to a minor league contract with an invitation to spring training. He was released by the White Sox on March 31, 2016.
On January 8, 2018, Lombardozzi signed a minor league deal with the Oakland Athletics. He elected free agency on November 2, 2018.
Long Island Ducks
On March 28, 2019, Lombardozzi signed a deal with the Long Island Ducks of the Atlantic League of Professional Baseball. He became a free agent following the season, but later re-signed with the Ducks for the 2020 season.
Personal life
His father, Steve Lombardozzi, played in the majors from 1985 to 1990.
