Suppressor of cytokine signaling 1


Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

Function

This gene encodes a member of the STAT-induced STAT inhibitor, also known as suppressor of cytokine signalling, family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin, GM-CSF, and interferon-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.
Several recent viral studies have shown that viral genes, such as Tax gene product, encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.

Interactions

The suppressor of cytokine signaling 1 has been shown to interact with: