In the Clinic link episodes, Dr. Tremayne, a psychiatrist in a modern mental asylum, reveals to colleague Dr. Nicholas that he has solved four special cases. Tremayne explains the case histories of patients Paul, Timothy, Brian, and Auriol, presenting each in turn to Nicholas: In Mr. Tiger, Paul is the sensitive and introverted young son of constantly bickering parents Sam and Fay Patterson. Amid the unhappy domestic situation he befriends an "imaginary" tiger. In Penny Farthing, antique store owner Timothy stocks a strange portrait of "Uncle Albert" and a penny farthing bicycle he has inherited from his aunt. In a series of episodes, Uncle Albert compels Timothy to mount the bicycle, and he is transported to an earlier era where he courts Beatrice, who was young Albert's love interest. These travels place Timothy's girlfriend Ann in peril. In Mel, Brian Thompson brings home an old dead tree, which he lovingly calls Mel, mounting it in his modern home as a bizarre piece of found object art. He increasingly shows unusual attention to Mel, angering his jealous wife Bella. In Luau, an ambitious literary agent, Auriol Pageant, lasciviously courts new client Kimo ; he shows more interest in her beautiful young daughter Ginny. Auriol plans a sumptuous luau for him; when the plans fall through, Kimo's associate Keoki takes over. The luau, as organised by Keoki, is actually a ceremony to assure Kimo's dying mother Malia passage to "heaven" by appeasing a Hawaiian god, and a requirement is that he consume the flesh of a virgin: Ginny. In the Epilogue, Tremayne watches as manifestations of the patients' histories materialise. Nicholas cannot see the manifestations and has Tremayne declared insane, apparently for believing the patients' bizarre accounts. Nicholas enters the patient holding area, and is killed by "Mr. Tiger".
Tales That Witness Madness was filmed at Shepperton Studios on 35 mm, with an aspect ratio of 1.85:1. It was the last film of Frank Forsyth, who appears as Uncle Albert. Jack Hawkins died shortly after his scenes were filmed. Hawkins had had his larynx removed in an operation in 1966, and here his voice was dubbed by Charles Gray in post-production. Tales That Witness Madness was Hawkins' final film appearance. Kim Novak broke a four-year hiatus from films with her appearance in Tales. She replaced Rita Hayworth shortly after production started.
Evaluation
The Encyclopedia of Horror writes that the film "avoids farce and develops a nicely deadpan style of humour which is ably sustained by the excellent cast in which only Novak appears unable to hit the right note."