Born in Brad, Hunedoara County, he was baptized in the town's Romanian Orthodox church. Around the age of five, he left for Buteni, his grandparents' village, located near the Crișul Alb River. Meleșcanu then studied at Moise Nicoară National College in Arad. He graduated from the Faculty of Law of the University of Bucharest in 1964 and the Faculty of Economic and Social Sciences of the University of Geneva in 1968. In 1973, he obtained a doctorate in political science and international law from the University of Geneva and the Graduate Institute of International Studies. Between 1966 and 1990 he held various diplomatic functions in the Ministry of Foreign Affairs. In August 1990 he was named undersecretary of state in this ministry. Between November 1992 and November 1996 he was the Minister of Foreign Affairs in Nicolae Văcăroiu's Party of Social Democracygovernment. In 1996 he campaigned as an independent for election to the Senate from the Prahova County electoral district. He was elected to that body, becoming president of the Foreign Affairs Committee of the Senate of Romania in the 1996–2000 legislature. In 1997, Meleșcanu founded the Alliance for Romania party, together with several former members of the PDSR. He was elected president of this party in December 1997 and re-elected in March 2001. In January 2002, in the wake of the Alliance for Romania's merger with the PNL, Meleșcanu became first vice-president of the latter party. Since 2004, he has been a Liberal senator for Prahova, also being a vice-president in the Permanent Bureau of the Senate. He is a professor at the Faculty of Political Sciences of the University of Bucharest, and has written a substantial number of works and scientific publications dealing with international law and diplomacy. On February 27, President Traian Băsescu appointed him for the SIE position vacant after the former director Mihai Răzvan Ungureanu's ascension to the post of Prime Minister. In 2013 he was awarded Commander's Cross with Star of the Order of Merit of the Republic of Poland. In November 2014, following the resignation of Titus Corlățean as a result of problems with voting in the Romanian diaspora during the first round of that year's presidential election, Meleșcanu was appointed foreign minister. He resigned eight days later, after similar problems took place during the second round. After his resignation, he joined the advisory board of the Fourth Ponta Cabinet regarding security and defense affairs. After Ponta was replaced by Dacian Cioloș, he was dismissed and joined ALDE. In January 2018 he became again Foreign Minister of Romania, this time in Dăncilă Cabinet. After thousands of Romanians living abroad have experienced difficulties in expressing their vote in the 2019 European Parliament election, Meleșcanu has been accused of premeditated abuse and obstruction of their right to vote. On the 6th of June 2019, The National Anticorruption Directorate announced that it has launched a criminal investigation in the matter. Meleșcanu is a Member of the Advisory Board of the , based in Berlin, Copenhagen, Prague, Sydney and Toronto, which works behind-the-scenes in conflict areas around the world.
Scientific activity
Apart from his diplomatic and political activity, Teodor Melescanu also did a didactic activity. He teaches as a professor at the Faculty of Political Sciences of the University of Bucharest, the Department of International Relations, being a holder of the courses "Public International Law", "European Security" and "The Principles and Practice of Diplomacy". He also teaches the "International Negotiation Theory and Practice" course at the Masters of the Faculty of Political Sciences of the University of Bucharest and the course "Public International Law" at the Masters Courses of the Faculty of History of the University of Bucharest. Meleşcanu published a wide range of scientific papers and publications related to international law and diplomacy. He is the vice-president of the Association of International Law and International Relations in Bucharest, a member of the Institute for Political Studies in Bucharest and of the Romanian Institute of International Studies.