Thallium poisoning


Thallium poisoning is poisoning due to thallium and its compounds which are often highly toxic. Contact with skin is dangerous, and adequate ventilation should be provided when melting this metal. Many thallium compounds are highly soluble in water and are readily absorbed through the skin. Exposure to them should not exceed 0.1 mg per m2 of skin in an 8 hour time-weighted average. Thallium is a suspected human carcinogen.
Part of the reason for thallium's high toxicity is that, when present in aqueous solution as the univalent thallium ion, it exhibits some similarities with essential alkali metal cations, particularly potassium. It can thus enter the body via potassium uptake pathways. Other aspects of thallium's chemistry differ strongly from that of the alkali metals, such as its high affinity for sulfur ligands. Thus, this substitution disrupts many cellular processes by interfering with the function of proteins that incorporate cysteine, an amino acid containing sulfur. Thallium's toxicity has led to its use as a rat and ant poison.
Among the distinctive effects of thallium poisoning are peripheral nerve damage and hair loss. However, hair-loss generally only occurs with low doses; with high doses, the thallium kills before this can take effect. Thallium was once an effective murder weapon, before its effects became understood and an antidote discovered. It has been called the "poisoner's poison" since it is colorless, odorless, and tasteless; its slow-acting, painful and wide-ranging symptoms are often suggestive of a host of other illnesses and conditions.

Cause

Bioconcentration

According to the United States Environmental Protection Agency, thallium release to the environment was reported in Texas and Ohio. This may indicate bioconcentration in aquatic ecosystems.

Thallium compounds

The odorless and tasteless thallium sulfate was also used as rat poison and ant killer. Since 1975, this use in the United States and many other countries is prohibited due to safety concerns.

Diagnosis

Thallium may be quantitated in blood or urine as a diagnostic tool in clinical poisoning situations or to aid in the medicolegal investigation of suspicious deaths. Normal background blood and urine concentrations in healthy persons are usually less than 1 μg/litre, but they are often in the 1–10 mg/litre range in survivors of acute intoxication.

Treatment

There are two main methods of removing both radioactive and stable isotopes of thallium from humans. First known was to use Prussian blue, which is a solid ion exchange material, which absorbs thallium. Up to 20 g per day of Prussian blue is fed by mouth to the person, and it passes through their digestive system and comes out in the stool. Hemodialysis and hemoperfusion are also used to remove thallium from the blood stream. At later stage of the treatment additional potassium is used to mobilize thallium from the tissue.

Notable cases

There are numerous recorded cases of fatal thallium poisoning. Because of its use for murder, thallium has gained the nicknames "The Poisoner's Poison" and "Inheritance Powder".

Australia's "Thallium Craze"

In Australia, in the early 1950s, there was a notable spate of cases of murder or attempted murder by thallium poisoning. At this time, due to the chronic rat infestation problems in overcrowded inner-city suburbs, and thallium's effectiveness as a rat poison, it was still readily available over the counter in New South Wales, where thallium sulphate was marketed as a commercial rat bait, under the brand "Thall-rat".
The Australian TV documentary Recipe for Murder, released in 2011, examined three of the most sensational and widely reported Australian thallium poisonings, the Fletcher, Monty, and Grills cases.

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