As of November 2010, the center houses three TOP500 supercomputers; the oldest and still fastest of which, a BlueGene/L system designed for protein folding simulations, called BGW, entered the list in the 06/2005 issue, then positioned second behind fellow Blue Gene/L in LLNL. Another well-known installation is Watson, an artificial intelligence system capable of answering natural language questions, which won several Jeopardy! games against human contestants in February 2011 on the site.
Buildings
;Yorktown Heights The Yorktown Heights building, housing the headquarters of IBM Research, is situated on private land not generally accessible to the public, is a large crescent-shaped structure consisting of three levels with 40 aisles each, radiating out from the center of the circle described as the crescent. Due to this construction, none of the offices have windows. The lowest level is partially underground in some areas toward the shorter side of the crescent, which also leads to the employee parking lots. A large overhang protrudes from the front entryway of the building, and faces the visitor parking lot. The building houses a library, an auditorium and a cafeteria. It was designed by the architect Eero Saarinen and built in 1956–1961. ;Albany NanoTech The facility can be found at 257 Fuller Rd, Albany, New York; it is located in facilities owned by the which also hosts the Center for Semiconductor Research. The IBM occupied portion of the site is the main facility of . The group focuses on next generation semiconductor technology research, and is the group most associated with a number of innovations related to semiconductor scaling, including the introduction of a 7 nm test chip in 2015 and a 5 nm test chip in 2017. This group operates an advanced extreme ultraviolet lithography enabled research line which is used to support their research both in support of and beyond traditional scaling. This work is done in a collaborative ecosystem based environment which includes academic and industrial partners. ;Cambridge The Cambridge research lab can be found at 75 Binney Street, Cambridge, Massachusetts; it is located in the IBM Watson Health HQ. Research at Cambridge focuses on AI. ;Hawthorne The Hawthorne building was a leased facility located on Skyline Drive, which is part of an industrial park shared by several area businesses. In 2012 the Hawthorne lease was closed by IBM and remaining employees were relocated to the Yorktown Heights site. The Hawthorne building is easily recognizable by its mirrored facade and large blue pole. Located approximately 25 miles north of New York City, the Hawthorne site was smaller than its sister site at Yorktown Heights. The primary focus at Hawthorne was software- and services-related research, whereas Yorktown Heights focuses on chemistry, mathematics, physics, silicon technology, and electrical engineering research, as well as some software and services. The building also contained a cafeteria, presentation center and library. The site, opened in 1984, was designed by Michael Harris Spector. The building is now part of New York Medical College