Tsikata held a Junior Research Fellowship at Oxford University where he also served as a tutor. On his return to Ghana in 1974, he was appointed a lecturer at the law faculty of the University of Ghana. Some of his students included Kwamena Ahwoi, Alban Bagbin, former majority leader in the Parliament of Ghana and Freddie Blay, former first deputy speaker in the Parliament of Ghana.
Barrister
Tsikata has served as counsel to a number of notable personalities over the years. These include Captain Kojo Tsikata, his cousin and Kofi Awoonor. During the era of the National Redemption Council/Supreme Military Council military regimes of Acheampong, he defended Samuel Okudjeto and William Ofori Atta who stood trial for political reasons. After the May 15 Uprising in 1979, he was counsel for Jerry Rawlings during the treason trial that came to an abrupt end when the SMC military government led by Fred Akuffo was overthrown on 4 June 1979. He was the lead Counsel for the ruling National Democratic Congress in an electoral petition in Ghana.
Tsikata was appointed the Chief Executive of the Ghana National Petroleum Company from October 1988 to December 2000 by the then ruling NDC led by Jerry Rawlings.
Trial, jail and pardon
Tsikata was tried for causing financial loss of GH¢230,000 to the state after a trial through the Accra Fast Track Tribunal, one of many set up by the Kufuor government to try such cases. The trial lasted for six years. He was pronounced guilty on 18 June 2008 by Mrs. Justice Hernrietta Abban. The length of the trial is reputed to be the longest ever involving a former government official in the history of the country. Those loyal to President Kufuor's New Patriotic Party government hailed this as a triumph for the judicial system while Tsikata's sympathisers and National Democratic Congress supporters saw the trial as politically motivated. This led to the formation of the "Free Tsatsu Movement". He was granted an unconditional pardon by the then President John Kufuor on his last day of office after his party, the New Patriotic Party lost the Ghanaian presidential election, 2008. At the time, he was on admission at the Korle Bu Teaching Hospital under prison guard following a severe bout of asthma. Tsatsu Tsikata rejected the presidential pardon and announced at a forum later that he felt the pardon was not in good faith and that he would fight through the court system to clear his name. He was the lead counsel for the NDC during the first ever electoral petition trial filed by the opposition New Patriotic Party challenging the results of the 2012 elections. The NDC filed a joinder to be the third respondent of this case.
Family
Tsikata is one of seven siblings. His father was Godwin Kwaku-Sru Tsikata, a retired Textiles Sales Manager with the United Africa Corporation. He is married to Esther Cobbah and they have three children. Award-winning Ghanaian musician, M.anifest, is one of his children
Personal and social life
Tsikata is Christian and an elder of the Asbury Dunwell Church in Accra. He is a known asthmatic and this appears to have limited his extracurricular activities and school attendance as a child. After he was jailed in 2008, he had an acute asthmatic attack that took him from the Nsawam prisons to intensive care.