Vernon Benjamin Mountcastle was born on July 15, 1918, in Shelbyville, Kentucky as the third of five children into a family of "farmers, industrial entrepreneurs, or builders of railroads". In 1921 his family moved to Roanoke, Virginia where he went to elementary and junior high school and was "an enthusiastic Boy Scout". Because his mother, a former teacher, had taught him to read and write when he was 4 years old, he immediately moved ahead two grades when entering the public school system and graduated high school at the age of 16. He entered Roanoke College in Salem, Virginia in 1935, in the midst of the Great Depression, where he majored in chemistry and finished in 3 years. While at Roanoke, he played tennis and was a member of the Sigma Chi Fraternity. In 1938 he started medical school at Johns Hopkins University where his teachers included William Mansfield Clark, Philip Bard, Adolf Meyer, Arnold Rice Rich, Maxwell Wintrobe, and Warfield Longcope. During his studies, Mountcastle planned to become a surgeon and never performed any experiments until after he returned from World War II. He joined the V-12 Navy College Training Program for medical students in January 1942, which allowed him to finish medical school and internship and was eventually ordered to report to the Naval Operating Base in Norfolk, Virginia in June 1943. Throughout the fall of 1943 and most of 1944 he was stationed in Africa and Europe and served on four LSTs during the Anzio and Normandy invasions. As he had received insufficient points for discharge from the Navy by the end of the war, he had to serve for one more year, which he spent at the Norfolk Naval Hospital as well as briefly serving on the USS Cadmus. He received his discharge from the Navy just before the Cadmus left for extended ocean duty.
Research and career
Mountcastle's interest in cognition, specifically perception, led him to guide his laboratory to studies that linked perception and neural responses in the 1960s. Although there were several notable works from his laboratory, the highest profile early paper appeared in 1968, a study explaining the neural basis of Flutter and vibration by the action of peripheral mechanoreceptors. In 1978 Mountcastle proposed that all parts of the neocortex operate through a common principle, with the cortical column being the unit of computation. Mountcastle's devotion to studies of single unit neural coding evolved through his leadership in the Bard Laboratories of Neurophysiology at the Johns Hopkins School of Medicine, which for many years, was the only institute in the world devoted to this sub-field. Its work is continued today in the Zanvyl Krieger Mind/Brain Institute. Mountcastle died in Baltimore at the age of 96 in January 2015.
