Ruffo began her acting career in 1980 starring in supporting roles in the telenovelaConflictos de un Médico, under the direction of Ernesto Alonso, and continued her career acting inAl Rojo vivo. In 1983, Valentín Pimsteín gave her the opportunity to star as the protagonist of La fiera as Natalia Ramirez together with Guillermo Capetillo. In 1985 she starred in Carlos Téllez's telenovela,Juana Iris alongside Valentín Trujjilo and her sister,Gabriela Ruffo. She worked in Ernesto Alonso's Victoria In 1989 Valentin Pimstein offered her the lead role in the telenovela Simplemente María.
1990s
In 1993 she was protagonist in "Capricho" a telenovela by Carlos Sotomayor as Cristina Aranda. In 1995 she was protagonist in Pobre Niña Rica a telenovela by Enrique Segoviano as Consuelo Villagrán. 1998,she starred in telenovela,Vivo por Elena as Elena Carvajal.
2000s
In 2000 she starred in Salvador Mejía's, Abrazame muy fuerte alongside Aracely Arámbula. In 2005 marked her comeback in the critically acclaimed telenovela La madrastra,which she starred with César Évora. After La madrastra, she performed duties as the First Lady of Pachuca, with her husband acting as mayor while continuing to star in the telenovelas. In 2007,Victoria starred in Telemundo production,Victoria alongside Arturo Peniche and Mauricio Ochmann. In 2008, she played protagonist in Carlos Moreno's,En nombre del amor together with, Leticia Calderón, Allisson Lozz and Altaír Jarabo.She played Macarena sister to Leticia Calderón's character,Carlota.
2010s
In 2010, she was named as one of Latin America's 50 Most Beautiful People. In mid 2010,she was confirmed to lead inSalvador Mejía Alejandre's telenovela,Triunfo del amor. She played "Victoria". She starred alongside Maite Perroni, William Levy and Diego Oliveira. After Triunfo del amor, Ruffo focused on her family and doing theater plays, specifically Dulce Pajaro de Juventud. She also went to support the senatorial campaign of her husband, Omar, who eventually won a seat in the senate. In 2012, José Alberto Castro confirmed her to star in telenovela,Corona de lágrimas,alongside José María Torre, Mané de la Parra, Alejandro Nones and Adriana Louvier.Due to her great performance in the latter she won the 31st TVyNovelas Awards for Best Lead Actress. In 2014, she played protagonist in telenovela, La malquerida alongside, Ariadne Díaz, Christian Meier, África Zavala and Arturo Peniche. In 2016 Salvador Mejia called her to lead the cast of the telenovela Las Amazonas In 2019 she was the protagonist of Cita a Ciegas a comic telenovela where Ruffo made the crossover to the comedy gender. Her role as Maura was well received and was the first telenovela where she didn't cry anymore.
