WAY-166818

WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research. It acts as a highly selective full agonist of the ERβ, with 57- and 164-fold selectivity for the ERβ over the ERα in the rat and mouse, respectively. At the human ERβ and ERα, WAY-166818 has IC₅₀ values of 29 nM and 1227 nM, respectively. The compound has been verified to cross the blood-brain-barrier in rodents.

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