1528

January–June

• January 12 - Gustav I of Sweden is crowned king of Sweden, having already reigned since his election in June 1523.
• February
• * Peasant uprising in Dalarna, Sweden: The rebel campaign fails, and the rebel leader, later known as Daljunkern, flees to Rostock.
• * Diego García de Moguer explores the Sierra de la Plata along the Río de la Plata, and begins to travel up the Paraná River.
• * Paracelsus visits Colmar in Alsace.
• April 28 - Battle of Capo d'Orso: The French fleet, under mercenary captain Filippino Doria, crushes the Spanish squadron trying to run the blockade of Naples.

  July–December

• September 12 - Andrea Doria defeats his former allies, the French, and establishes the independence of Genoa.
• October 3 - Álvaro de Saavedra Cerón arrives in the Maluku Islands.
• October 13 - Cardinal Thomas Wolsey founds a college in his birthplace of Ipswich, England, which becomes the modern-day Ipswich School.
• October 20 - The Treaty of Gorinchem is signed between Charles V, Holy Roman Emperor, and Charles, Duke of Guelders.
• November 6 - Spanish conquistador Álvar Núñez Cabeza de Vaca and his companions become the first known Europeans to set foot on the shores of what is present-day Texas.

  Date unknown

• Montenegro gains autonomy under Ottoman power.
• Spanish Conquistador Francisco de Montejo attempts an invasion of the Yucatán, but is driven out by the Maya peoples.
• Spain takes direct control of Acapulco.
• Bubonic plague breaks out in England.
• The fourth major outbreak of the sweating sickness occurs in England. This time the disease also spreads to northern Europe.
• St George's Chapel in Windsor Castle is completed.
• Chateau Fontainebleau in France is begun.
• Michelangelo Buonarroti begins work on the fortifications of Florence.
• Baldassare Castiglione publishes The Book of the Courtier.
• In Henan province, China, during the mid Ming dynasty, a vast drought deprives the region of harvests for the next two years, killing off half the people in some communities, due to starvation and cannibalism.
• Paracelsus leaves Basel.
• Perak Sultanate is established at Perak Darul Ridzuan.
• Johor Sultanate is established at Johor Darul Takzim.

  Births

• February 29
• * Domingo Báñez, Spanish theologian
• * Albert V, Duke of Bavaria
• March 10 - Akechi Mitsuhide, Japanese samurai and warlord
• March 25 - Jakob Andreae, German theologian
• June 7 - Cyriacus Spangenberg, German theologian and historian
• June 21 - Maria of Austria, Holy Roman Empress
• June 29 - Julius, Duke of Brunswick-Lüneburg
• July 7 - Archduchess Anna of Austria, Duchess of Bavaria
• July 8 - Emmanuel Philibert, Duke of Savoy
• July 26 - Diego Andrada de Payva, Portuguese theologian
• August 10 - Eric II, Duke of Brunswick-Lüneburg
• September 25 - Otto II, Duke of Brunswick-Harburg
• October 4? - Francisco Guerrero, Spanish composer
• October 10 - Adam Lonicer, German botanist
• November 2 - Petrus Lotichius Secundus, German Neo-Latin poet
• November 6 - Gabriel Goodman, Dean of Westminster
• November 12 - Qi Jiguang, Chinese military general
• November 14 - Francisco Pérez de Valenzuela, Spanish noble
• November 16 - Jeanne d'Albret, Queen of Navarre
• November 29 - Anthony Browne, 1st Viscount Montagu, English politician
• date unknown
• * Igram van Achelen, Dutch statesman
• * Adam von Bodenstein, Swiss alchemist and physician
• * Jean-Jacques Boissard, French antiquary and Latin poet
• * Andrey Kurbsky, Russian writer
• * George Talbot, 6th Earl of Shrewsbury, English statesman
• * Phùng Khắc Khoan, Vietnamese military strategist, politician, diplomat and poet
• * Sabina, Duchess of Bavaria
• * Tanegashima Tokitaka, Japanese daimyō
• * Thomas Whythorne, English musician and author
• probable
• * Ambrose Dudley, 3rd Earl of Warwick, English general
• * Paul de Foix, French diplomat
• * Jean de Ligne, Duke of Arenberg, stadtholder of the Dutch provinces of Friesland
• * Costanzo Porta, Italian composer

  Deaths

• January 30 - Maharana Sangram Singh, Rana of Mewar
• February 29 - Patrick Hamilton, Scottish religious reformer
• March 10 - Balthasar Hübmaier, influential German/Moravian Anabaptist leader
• April 1 - Francisco de Peñalosa, Spanish composer
• April 6 - Albrecht Dürer, German artist, writer, and mathematician
• July - Palma il Vecchio, Italian painter
• August 15 - Odet de Foix, Vicomte de Lautrec, French military leader
• August 20 - Georg von Frundsberg, German knight and landowner
• August 23 - Louis, Count of Vaudémont, Italian bishop
• August 31 - Matthias Grünewald, German artist
• September - Pánfilo de Narváez, Spanish conqueror and soldier in the Americas
• October 5 - Richard Foxe, English churchman
• October 18 - Michele Antonio, Marquess of Saluzzo
• October 21 - Johann of Schwarzenberg, German judge and poet
• November 17 - Jakob Wimpfeling, Renaissance humanist
• December 7 - Margaret of Saxony, Duchess of Brunswick-Lüneburg
• date unknown
• * Giovanni da Verrazzano, Italian explorer
• * Peter Vischer the Younger, German sculptor
• * Mahmud Shah of Malacca, Malaccan sultan
• * Daljunkern, Swedish rebel leader who may have been pretender Nils Sture
• * Barbro Stigsdotter, Swedish noblewoman and heroine