List of biophysicists

A

• Gary Ackers — thermodynamics of protein assembly into complexes, protein-DNA interactions and enzyme subunit interactions
• David Agard
• Christian B. Anfinsen — author of the postulate about spontaneous protein folding, for which he received a Nobel Prize

  B

• Robert L. Baldwin — protein folding
• David Baker — Protein structure prediction; protein design; Rosetta software
• Adriaan Bax — development of methodology for NMR spectroscopy
• Georg von Békésy — research on the human ear
• Boris Pavlovich Belousov — known for discovery of Belousov–Zhabotinsky reaction
• Howard Berg — characterized properties of bacterial chemotaxis
• Helen M. Berman — pioneer in study of nucleic acid structure; head of the worldwide Protein Data Bank
• John Desmond Bernal — X-ray crystallography of plant viruses and proteins
• Pamela J. Bjorkman — first X-ray crystallography of human histocompatibility complex; studies immune recognition, homologs of MHC proteins, and improved antibodies against HIV
• Steven Block — observed the motions of enzymes such as kinesin and RNA polymerase with optical tweezers
• Sir Tom Blundell — crystal structures of HIV protease, renin, insulin and other hormones, growth factors, receptors, and proteins important in cell signalling and DNA repair; developed structure-guided and fragment-based approaches to drug design
• Jagadish Chandra Bose
• Detlev Wulf Bronk
• Axel Brunger — developed the free R cross-validation index and the X-PLOR/CNS software for macromolecular crystallography
• Carlos Bustamante — known for single-molecule biophysics of molecular motors and biological polymer physics

  C

• Charles Cantor — Director, Center for Advanced Biotechnology, Boston University. Cantor is a molecular geneticist who developed pulse field electrophoresis for very large DNA molecules with David C. Schwartz in 1984, by adding an alternating voltage gradient to standard gel electrophoresis.
• Donald Caspar — theory of quasi-equivalence in icosahedral viruses
• Alexander Chizhevsky — founder of heliobiology
• Wah Chiu — cryo electron microscopy; virus structure; high-resolution cryoEM
• Steven Chu — Nobel laureate who helped develop optical trapping techniques used by many biophysicists
• G. Marius Clore FRS — pioneer of multidimensional macromolecular NMR spectroscopy laying foundations of 3D structure determination of proteins in solution, and discovery of rare, invisible conformational states of macromolecules
• Carolyn Cohen — in 1969, Cohen codiscovered the molecular structure of tropomyosin as a polar coiled coil, also being the first protein crystal structure determined with a 20Å resolution via x-ray crystallography. On the route to this discovey, she also discovered a novel crystal structure, termed the Cohen-Longley paracrystal with 400Å periodicity, in 1966.
• Robert Corey — co-discoverer of the alpha helix and beta sheet structures in proteins
• Allan McLeod Cormack — development of computer assisted tomography
• Christoph Cremer — overcoming the conventional limit of resolution that applies to light based investigations by a range of different methods like SPDM and SMI
• Francis Crick — co-discoverer of the structure of DNA. Later participated in the Crick, Brenner et al. experiment which established the basis for understanding the genetic code.

  D

• Johann Deisenhofer — solved first three-dimensional structure of membrane protein
• Max Delbrück — discovered that bacteria become resistant to phages as a result of genetic mutations. Delbrück, Salvador Luria, and Alfred Hershey shared the 1969 Nobel Prize in Physiology or Medicine "for their discoveries concerning the replication mechanism and the genetic structure of viruses"
• Emilio Del Giudice — water research
• David DeRosier — developed 3-D reconstruction methods for electron microscopy
• Friedrich Dessauer — research on radiation, especially X-rays
• Ken A. Dill — research on folding pathways of proteins.
• Christopher Dobson — protein folding and misfolding
• Jennifer Doudna — structures of large RNAs; pioneer in CRISPR research
• Leslie Dutton — Oxidoreductase function and design.

  E

• Richard H. Ebright — single-molecule enzymology; structure and function of RNA polymerases
• Gerald M. Edelman — Nobel laureate, structure of antibodies
• David Eisenberg
• Donald Engelman
• S. Walter Englander
• Richard R. Ernst — developer of two-dimensional nuclear magnetic resonance spectroscopy

  F

• George Feher — photosynthesis mechanisms for plants and bacteria
• Julio M. Fernandez
• Alan Fersht — pioneered work on protein folding
• Adolf Eugen Fick — responsible for Fick's law of diffusion and a method to determine cardiac output
• Joachim Frank — pioneered single-particle reconstruction in electron microscopy; studied structure and dynamics of ribosomes.
• Rosalind Franklin — pioneer of DNA crystallography and co-discoverer of the structure of DNA
• Clara Franzini-Armstrong
• Hans Frauenfelder — pioneering work on experiment and theory to understand dynamic behavior in protein structure

  G

• Luigi Galvani — discoverer of bioelectricity
• Walter Gilbert — Nobel laureate; introduced intron/exon concept, proposed RNA world hypothesis
• Angela Gronenborn —member of National Academy of Sciences
• Martin Gruebele — Protein Folding

  H

• Taekjip Ha — single-molecule biophysics
• Hermann von Helmholtz — first to measure the velocity of nerve impulses; studied hearing and vision
• Stefan Hell — developed the principle of STED microscopy
• Richard Henderson — scientist at the MRC Laboratory of Molecular Biology, developed the use of cryo-EM to study membrane protein structures.
• Wayne Hendrickson — developed robust methods of phasing and refinement for protein crystallography
• A.V. Hill — Nobel laureate, Hill coefficient for cooperativity in enzyme kinetics, physics of nerves and muscles
• Alan Hodgkin — mathematical theory of how ion fluxes produce nerve impulses
• Dorothy Hodgkin — winner of the 1964 Nobel Prize in Chemistry, known for determining the structures of penicillin, vitamin B12, and insulin
• Alexander Hollaender — founded the science of radiation biology; early evidence for nucleic acid as the genetic material
• Barry H. Honig — pioneered theory and computation for electrostatics in biological macromolecules
• John J. Hopfield — worked on error correction in transcription and translation, and associative memory models
• Arthur L. Horwich — chaperonins
• Godfrey Hounsfield — development of computer assisted tomography
• Wayne L. Hubbell — circa 1989, he oversaw the development of the technique termed site-directed spin labeling, used for determining protein structure and dynamics through genetically creating an attachment point for a nitroxide spin labeled probe. The technique allows insight on the nature of how a protein's structure and conformational changes create/form protein function.
• Andrew Huxley — mathematical theory of how ion fluxes produce nerve impulses
• Hugh Huxley — muscle structure and contraction
• James S. Hyde — Developer of EPR and MRI instrumentation, holder of 35 U.S. Patents

  I

• Shinya Inoué — cytoskeletal dynamics

  J

• Louise Johnson — Crystal structure of lysozyme with David Phillips, then glycogen phosphorylase. Wrote influential crystallography textbook with Tom Blundell.
• Pascual Jordan

  K

• Martin Karplus — research on molecular dynamical simulations of biological macromolecules.
• Michael Kasha — founder of Institute of Molecular Biophysics at Florida State University
• Bernard Katz — discovered how synapses work
• Ephraim Katzir
• Walter Kauzmann — was one of the first to recognize the role of hydrophobic effect in protein folding
• Jeffery W. Kelly — protein misfolding and aggregation
• John Kendrew — pioneer of protein crystallography
• Dorothee Kern
• Aaron Klug — winner of the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes
• Brian Kobilka — winner of the 2012 Nobel Prize in Chemistry for his work on the structure and activity of G-protein-coupled receptors
• Stephen Kowalczykowski — "visual biochemistry" of DNA repair and homologous recombination
• John Kuriyan

  L

• Robert S. Langer — biotechnology, drug delivery, and tissue engineering; Wolf Prize in Chemistry; Priestley Medal
• Paul Lauterbur — development of magnetic resonance imaging
• Stephen D. Levene — DNA-protein Interactions, DNA looping, and DNA topology
• Michael Levitt — winner of the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems
• Karolin Luger — studies of chromatin and nucleosome structure.

  M

• Roderick MacKinnon — determined first three-dimensional structure of voltage-gated transmembrane ion channel
• David H. MacLennan
• Marvin Makinen — pioneer of the structural basis of enzyme action
• Peter Mansfield — development of magnetic resonance imaging
• Brian W. Matthews — explicated the energetic and structural effects of mutations in proteins, using phage T4 lysozyme studied by protein crystallography
• Ann McDermott — study of biological samples using solid-state NMR
• Martti Mela
• Peter D. Mitchell — discovered the chemiosmotic mechanism of ATP synthesis
• Manuel Morales — molecular basis of muscle contraction
• Hermann Joseph Muller — discovered that X-rays cause mutations

  N

• Erwin Neher — development of the patch clamp and single-channel recording
• Eva Nogales — electron microscopy; microtubule dynamics

  O

• Seiji Ogawa — development of functional magnetic resonance imaging
• Wilma Olson — Professor at Rutgers, pioneer in study of DNA structure

  P

• George Palade — Nobel Laureate in physiology or medicine for protein secretion and cell ultra-structure from electron microscopy studies
• Linus Pauling — co-discoverer of the alpha helix and beta sheet structures in proteins
• Max Perutz — pioneer of protein crystallography
• Massimo Piatelli-Palmarini — biophysicist and cognitive scientist; organized the first conference on biolinguistics
• Ernest C. Pollard — founder of the Biophysical Society
• Fritz-Albert Popp — biophoton research and coherence systems in biology
• Oleg Ptitsyn —protein folding
• Joseph D. Puglisi — pioneered applications of NMR spectroscopy in studying RNA structure and single-molecule fluorescence microscopy in studying the dynamics of protein synthesis
• Bernard Pullman — pioneered applications of Quantum Chemistry in Biology

  Q

R

• Sir George Radda — early developer of Magnetic Resonance Imaging
• Gopalasamudram Narayana Iyer Ramachandran — famous for the Ramachandran plot of protein backbone conformation
• Venkatraman Ramakrishnan — winner of 2009 Nobel Prize in Chemistry for crystal structure of the 30S subunit of the bacterial ribosome
• Ayyalusamy Ramamoorthy — solid-state NMR
• Sir John Randall — X-ray and neutron diffraction of proteins and DNA
• Zihe Rao — structural biologist, member Chinese Academy of Sciences, president of Nankai University
• Nicolas Rashevsky, former Editor of the first journal of mathematical and theoretical biophysics entitled " The Bulletin of Mathematical Biophysics " and author of the two-factor model of neuronal excitation, biotopology and organismic set theory
• Frederic M. Richards
• Jane Richardson — developed the ribbon diagram for representing the 3D structure of proteins; with husband David, developed MolProbity structure-validation web service
• Robert Rosen — theoretical biophysicist and mathematical biologist, author of: metabolic-replication systems, categories of metabolic and genetic networks, quantum genetics in terms of von Neumann's approach, non-reductionist complexity theories, dynamical and anticipatory systems in biology.
• Michael Rossmann — worked with Max Perutz on the crystal structure of hemoglobin, then in his own lab solved structures of enzymes including lactate dehydrogenase, the prototype of the Rossmann fold, and of many viruses including the common cold virus.
• Benoit Roux — continues to conduct research at the University of Chicago in classical molecular dynamics and other theoretical techniques to determine the function of biological systems on the molecular level. He is a distinguished pioneer in the study of membrane proteins and bridging the gap between theoretical and experimental biophysics through computation.

  S

• Erich Sackmann — founder of the bottom-up approach to understanding of the cell mechanics and adhesion
• Bert Sakmann — development of the patch clamp and single-channel recording
• Francis O. Schmitt
• Simon Shnoll — worked in the fields of chemical clocks, Chronobiology and Astrobiology.
• Timothy Springer
• James Spudich — molecular motors
• Thomas A. Steitz
• Lubert Stryer
• Attila Szabo — Founders award of the Biophysical Society for theoretical analysis of biophysics experiments

  T

• Janet Thornton — Director of the European Bioinformatics Institute; early pioneer in structural and functional bioinformatics, including the development of ProCheck for structure validation and CATH for protein structure classification
• Nikolay Timofeev-Ressovsky — one of pioneers in radiation biology
• Ignacio Tinoco
• Chikashi Toyoshima — Ca-ATPase ion pump
• Roger Tsien — Nobel laureate who pioneered the use of green fluorescent protein for biological imaging

  V

• Jerome Vinograd — developed density gradient ultracentrifugation
• Steven Vogel — biomechanics
• Mikhail Volkenshtein

  W

• Douglas Warrick — specializing in bird flight
• Arieh Warshel — development of QM/MM approaches for a quantitative understanding of enzymatic reactions; introduction of molecular dynamics simulations in biology; introduction of consistent electrostatic calculations in proteins.
• James D. Watson — co-discoverer of the structure of DNA.
• Anthony Watts — early proponent of the idea of both structural and functional significance of “Lipid-protein interactions”, and developer of solid state NMR for biology.
• Watt W. Webb — developer of multiphoton microscopy
• Gregorio Weber
• John Wikswo — research on biomagnetism and cardiac electrophysiology
• Don Craig Wiley — applied molecular biophysics to study of viruses
• Maurice Wilkins — pioneer of DNA crystallography and co-discoverer of the structure of DNA.
• Kurt Wüthrich — Nobel Laureate in physiology or medicine for 2D-FT NMR of protein structure in solution

  X

• Sunney Xie — single-molecule enzymology

  Y

• King-Wai Yau — fundamental contributions to understanding the mechanisms of sensory transduction in rod, cone, and non-image visual systems and in olfaction
• Ada Yonath — winner of the 2009 Nobel Prize in Chemistry for solving the crystal structure of the large subunit of the ribosome
• Douglas Youvan — light reactions of photosynthesis, genetic code, imaging spectroscopy and directed evolution

  Z

• Bruno Zimm — co-developer of the Zimm-Bragg model of helix formation